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CONTENTS ENVIRONMENTAL Health Criteria FOR POLYBROMINATED BIPHENYLS (PBBs) 1.
SUMMARY AND Evaluation, CONCLUSIONS AND Recommendations 1.1. Summary and evaluation 1.1.1. Identity, bodily and chemical homes, analytical methods 1.1.2. Sources of human and environmental exposure 1.1.3. Environmental transport, distribution, and transformation 1.1.4.
Environmental amounts and human publicity 1.1.5. Kinetics and fat burning capacity 1.1.6. Effects on organisms in the environment 1.1.7. Effects on experimental animals and in vitro examination methods 1.1.8. Effects on people 1.1.9. Overall evaluation of toxicity and carcinogenicity 1.2.
Conclusions 1.3. Recommendations 1.3.1. General 1.3.2. Future study 2. Identity, Physical AND CHEMICAL Properties, ANALYTICAL Methods 2.1. Identity 2.1.1. Primary constituents 2.1.2. Technical merchandise 2.1.2.1 Major trade names 2.1.2.2 Composition of the complex merchandise 2.2.
Physical and chemical qualities 2.2.1. Physical and chemical attributes of person congeners 2.3. Conversion components for PBB in air 2.4. Analytical approaches three. Sources OF HUMAN AND ENVIRONMENTAL Exposure 3.1. Natural occurrence 3.2. Man-manufactured resources 3.2.1.

Production concentrations and processes 3.2.1.1 World creation figures 3.2.1.2 Manufacturing procedures 3.2.1.3 Loss into the setting for the duration of standard output 3.2.1.4 Methods of transport, accidental launch, and disposal of creation wastes 3.2.2. Uses four.

ENVIRONMENTAL Transport, DISTRIBUTION AND TRANSFORMATION 4.1. Transport and distribution between media 4.1.1. Air 4.1.2. Water 4.1.3. Soil 4.1.4. Biota 4.1.4.1 Terrestrial ecosystems 4.1.4.2 Aquatic ecosystems 4.1.4.3 Accidental contamination of the food chain 4.2.

Degradation 4.2.1. Photolytic degradation 4.2.2. Microbial degradation 4.2.3. Degradation by vegetation and animals 4.2.4. Bioaccumulation 4.2.4.1 Aquatic organisms 4.2.4.2 Terrestrial organisms 4.3. Ultimate destiny following use 4.3.1. Disposal of PBB-contaminated animals and wastes from the Michigan disaster 4.3.2.

Thermal decomposition of PBBs 5. ENVIRONMENTAL Levels AND HUMAN Exposure 5.1. Environmental degrees 5.1.1. Air 5.1.2. Water and sediments 5.1.2.1 Surface waters 5.1.2.2 Sediments 5.1.2.3 Groundwater 5.1.3. Soil 5.1.4. Feed and food 5.1.4.1 Feed 5.1.4.2 Food 5.1.5. Other merchandise 5.1.6.
Terrestrial and aquatic organisms 5.1.6.1 Aquatic and terrestrial plants 5.1.6.2 Animals 5.2. General population exposure 5.2.1. Quantified info on human exposure 5.2.1.1 Worldwide 5.2.1.2 The Michigan accident 5.2.2. Human monitoring solutions for PBBs 5.2.3.
Human checking information 5.2.4. Subpopulations at distinctive possibility 5.3. Occupational exposure in the course of manufacture, formulation, or use 6. KINETICS AND Metabolism 6.1. Absorption 6.1.1. Animal reports 6.1.1.1 Gastrointestinal absorption 6.1.1.2 Dermal and inhalation absorption 6.1.2.

Human research 6.2. Distribution 6.2.1. Animal scientific tests 6.2.1.1 Levels in organs and blood 6.2.1.2 Transfer to offspring 6.2.2. Human scientific tests 6.3. Metabolic transformation 6.3.1. In vitro scientific tests 6.3.2. In vivo scientific studies 6.3.3.
Metabolic pathway 6.4. Elimination and excretion in expired air, faeces, urine 6.4.1. Animal scientific studies 6.4.2. Human studies 6.5. Retention and turnover 6.5.1. Animal experiments 6.5.1.1 Time developments, retention: 2,2',4,4',5,5'-hexabromobiphenyl (BB 153) 6.5.1.2 Biological 50 percent-lives 6.5.1.3 Differences involving specific congeners 6.5.1.4 Octabromobiphenyl 6.5.2.
Human reports 6.6. Reaction with physique elements 6.6.1. Animal experiments 6.6.2. Human studies 7. Effects ON ORGANISMS IN THE Environment 7.1. Microorganisms 7.2. Aquatic organisms 7.3. Terrestrial organisms 7.3.1. Wildlife 7.3.2. Farm animals 7.3.2.1 Cattle 7.3.2.2 Other farm animals 7.4.
Population and ecosystem effects 7.5. Effects on the abiotic atmosphere 8. Effects ON EXPERIMENTAL ANIMALS AND IN VITRO Test Systems 8.1. Lethality 8.2. Single and small-expression exposures: normal indicators of toxicity 8.2.1. PBB mixtures 8.2.1.1 Overt medical indicators, foodstuff ingestion, and physique fat alterations 8.2.1.2 Haematology and scientific chemistry 8.2.1.3 Morphological and histopathological changes 8.2.2.
Individual PBB congeners and comparative scientific studies 8.2.2.1 Food consumption, overt clinical signals, physique excess weight changes 8.2.2.2 Haematology and scientific chemistry 8.2.2.3 Morphological and histopathological alterations 8.3. Skin and eye discomfort, sensitization, dermal lesions, and zits 8.4.
Long-time period toxicity 8.4.1. Rat 8.4.1.1 Overt clinical signs, overall body weight variations, food ingestion 8.4.1.2 Haematology and scientific chemistry 8.4.1.3 Morphological improvements 8.4.1.4 Histopathological modifications 8.4.2. Mouse 8.4.3. Cattle 8.4.4.
Mink 8.4.5. Rhesus monkey 8.4.6. Pre- and perinatal publicity 8.5. Reproduction, embryotoxicity, and teratogenicity 8.5.1. PBB mixtures 8.5.1.1 Mammals 8.5.1.2 Avian species 8.5.2. Individual PBB congeners 8.6. Mutagenicity and connected end-points 8.7. Carcinogenicity 8.7.1.
Carcinogenicity in very long-expression toxicity studies 8.7.2. Mechanisms of carcinogenicity 8.7.2.1 Tumour initiation eight. 7.2.2 Tumour promotion 8.7.2.3 PBBs performing as finish carcinogens 8.8. Biochemical toxicity 8.8.1. Induction of microsomal enzymes 8.8.1.1 Commercial PBB mixtures 8.8.1.2 Individual PBB congeners 8.8.2.

Endocrine interactions 8.8.2.1 Thyroid hormones 8.8.2.2 Sex hormones 8.8.2.3 Prostaglandins 8.8.3. Interaction with prescription drugs and toxicants 8.8.4. Effect on vitamin A storage 8.8.5. Porphyria 8.8.6. Miscellaneous consequences 8.9. Effects on intercellular conversation 8.10.
Immunotoxicity 8.11. Neurotoxicity 8.11.1. Exposure of grownup animals 8.11.2. Perinatal exposure 8.12. Factors modifying toxicity, toxicity of metabolites 8.12.1. Contaminants affecting toxicity 8.12.1.1 Polybrominated naphthalenes (PBNs) 8.12.1.2 Mixed polybromo-chlorobiphenyls 8.12.2.
Toxicity of metabolites 8.12.3. Toxicity of photolysis and pyrolysis merchandise 8.12.3.1 Photolysis products and solutions 8.12.3.2 Pyrolysis products 8.13. Mechanism of toxicity such as carcinogenicity nine. Effects ON Humans 9.1. General populace exposure 9.1.1.
Acute toxicity-poisoning incidents 9.1.2. Epidemiological scientific studies 9.1.2.1 Studies carried out by the Michigan Department of Public Health (MDPH studies) 9.1.2.2 Studies performed by the Environmental Science Laboratory, Mount Sinai School of Medicine, New York (ESL scientific studies) 9.1.3.
Special studies 9.1.3.1 Examination of subjects with grievances 9.1.3.2 Cutaneous outcomes 9.1.3.3 Effects on liver perform 9.1.3.4 Porphyria 9.1.3.5 Effects on spermatogenesis 9.1.3.6 Paediatric elements 9.1.3.7 Neurological and neuropsychiatric factors 9.1.3.8 Lymphocyte and immune purpose 9.1.3.9 Carcinogenic embryonic antigen plasma degrees 9.1.3.10 Biochemical results 9.2.
Occupational exposure 9.2.1. Epidemiological experiments 9.2.2. Clinical studies 9.2.3. Special scientific studies 9.2.3.1 Cutaneous effects 9.2.3.2 Memory performance 9.2.3.3 Thyroid consequences 9.2.3.4 Reproductive outcomes 9.2.3.5 Lymphocyte function 9.2.3.6 Mortality 10.
Previous EVALUATIONS BY International BODIES REFERENCES ANNEX 1 RESUME ET Evaluation, CONCLUSIONS ET RECOMMANDATIONS RESUMEN Y EVALUACION, CONCLUSIONES Y RECOMENDACIONES WHO Task Group ON ENVIRONMENTAL Health Criteria FOR POLYBROMINATED BIPHENYLS Members Dr L. Albert, Consultores Ambientales Asociados, S.C., Xalapa, Veracruz, Mexico Dr J.

Alexander, Department of Toxicology, National Institute of Public Health, Oslo, Norway Dr W. Gross, Fraunhofer Institute for Toxicology and Aerosol Research, Hanover, Germany Dr R.F.

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